Inflammatory bowel disease in pregnancy
Conceiving in remission, which IBD drugs to continue or stop (methotrexate, JAK inhibitors, S1P modulators), assessing a flare in pregnancy, mode of birth, breastfeeding and live vaccines in biologic-exposed infants.
Tier 1Condition
Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made
At a glance
- IBD often affects women in their reproductive years. With disease in remission, fertility and pregnancy outcomes are close to normal.
- Active disease, not medication, is the main threat: it raises miscarriage, preterm birth, low birth weight and small-for-gestational-age risk.
- Plan conception after 3 to 6 months of remission. Continue most maintenance drugs, including anti-TNF and other biologics throughout pregnancy.
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Sources
- Global consensus statement on the management of pregnancy in inflammatory bowel diseaseMahadevan U et al. (Global Consensus Consortium), published simultaneously in Gut, J Crohns Colitis, Inflamm Bowel Dis, Clin Gastroenterol Hepatol, Aliment Pharmacol Ther and Am J Gastroenterol, 2025 to 2026, 2025
- Australian inflammatory bowel disease consensus statements for preconception, pregnancy and breast feedingAU/NZLaube R et al. Gut 2023;72:1040-53, 2023
- European Crohn's and Colitis Guidelines on sexuality, fertility, pregnancy, and lactationTorres J et al. J Crohns Colitis 2023;17:1-27, 2023
- Inflammatory bowel disease in pregnancy clinical care pathway: a report from the American Gastroenterological Association IBD Parenthood Project Working GroupMahadevan U et al. Gastroenterology 2019;156:1508-24, 2019 (superseded on most points by the 2025 Global Consensus)
- Therapeutic Guidelines: Gastrointestinal (inflammatory bowel disease in pregnancy)AU/NZTherapeutic Guidelines Limited
- Australian Immunisation Handbook (vaccination of infants exposed to immunosuppressive therapy in utero)AU/NZAustralian Technical Advisory Group on Immunisation, Australian Government
- Last updated
- 14 November 2026
What changed
- 14 November 2026 Turnstile bot check on sign-in and signed-out feedback