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Cardiology

Hypertrophic cardiomyopathy

Diagnosis by wall thickness, LVOT obstruction and its drugs, myosin inhibitors and the PBS, sudden death risk and ICDs, phenocopies, AF and family screening.

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Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made

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At a glance

  • The commonest inherited heart disease: unexplained LV hypertrophy in about 1 in 500 adults. Mostly autosomal dominant sarcomere gene variants.
  • Diagnosis: wall thickness ≥15 mm (≥13 mm in a first-degree relative) not explained by loading conditions.
  • About two-thirds have LV outflow tract obstruction at rest or on provocation, which drives symptoms and is the target of most treatment.

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Last updated
14 November 2026
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