Central line and intravascular catheter infections
Diagnosing catheter-related bloodstream infection with paired cultures, when the line must come out, lock therapy, durations by organism, catheter-related thrombosis and the insertion bundle.
Tier 1Condition
Written with AI assistance and fact-checked against the sources below. For exam study, not clinical decisions. How notes are made
At a glance
- Intravascular catheters cause a large share of healthcare-associated bloodstream infection, including S. aureus bacteraemia from peripheral cannulas, which are often forgotten.
- Diagnosis rests on paired blood cultures (one through the catheter, one peripheral) and the absence of another source.
- S. aureus, Pseudomonas, Candida and mycobacteria mean the line comes out. Coagulase-negative staphylococci can sometimes be treated with the line in place.
Loading the rest of the note…
Finished reading?
Sources
- Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 updateInfectious Diseases Society of America (Mermel et al., Clinical Infectious Diseases), 2009 (archived by IDSA; no replacement found as of November 2026; ESCMID guideline in development)
- Therapeutic Guidelines: Antibiotic. Intravascular catheter-related infectionsAU/NZTherapeutic Guidelines Limited (eTG complete), current eTG edition (topic version not verified)
- Management of Peripheral Intravenous Catheters Clinical Care StandardAU/NZAustralian Commission on Safety and Quality in Health Care, 2021
- Rickard CM et al. Routine versus clinically indicated replacement of peripheral intravenous catheters: a randomised controlled equivalence trial. Lancet 2012;380:1066-74AU/NZThe Lancet, 2012
- Antibiotic treatment for 7 versus 14 days in patients with bloodstream infections (BALANCE trial)New England Journal of Medicine (Daneman et al.), 2025
- Last updated
- 14 November 2026
What changed
- 14 November 2026 Turnstile bot check on sign-in and signed-out feedback